Antibodies & immunoassays for small molecules Quinolinic Acid ELISA kit
High Sensitivity, Plasma & Serum
Ref: IS-I-0100R
Kynurenine pathwayTryptophan metabolismToxinsResearch ELISA kits (RUO)ELISA
+Quinolinic acid ELISA kit
DatasheetMSDSProtocol
Quinolinic acid (QA) is a metabolite produced along the Kynurenine Pathway, which converts the aminoacid Tryptophan to NAD+, a co-factor of many enzymatic reactions.
The Quinolinic Acid ELISA kit is optimized for the quantitation of Quinolinic Acid (QUIN or QA) within serum and plasma samples. This easy-to-use competitive assay is well-suited for both small and large series of samples. Working with a low sample volume of 25µL, this assay enables pre-clinical and clinical sample testings.
| Sample type | Serum, Plasma |
| Capacity | 96 tests |
| Sensitivity | 35.9nM |
| Range | 150 – 12150nM |
| Assay time | Sample acylation 120 min, ELISA overnight |
| Reactivity | Reacts with all species |
| References | Cited in 10 papers |
They published with this product see papers
Product overview
| Product name | Quinolinic Acid ELISA kit |
| Description | Competitive ELISA kit for the quantitative measurement of Quinolinic Acid levels in serum and plasma samples. For research use only |
| Format | 96-well plate |
| Samples | Serum, Plasma |
| Minimal sample volume | 25µL |
| Reactivity | Reacts with all species |
| Standard range | 25 – 2000ng/mL |
| Sensitivity |
< 6ng/mL |
| Specificity | No significant cross-reactivity was observed with Quinolinic Acid analogs such as Kynurenic acid, Xanthurenic acid, Kynurenine, Picolinic acid, 3-Hydroxy-Anthranilic Acid |
| Assay time | Sample acylation 120 min and ELISA overnight |
| Storage | Store at 2-8°C for up to 6 months |
| Datasheets | Instructions for use, Material Safety Datasheet |
| Sample collection & storage | Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands
Plasma (Heparin) Store samples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months) |
| Sample preparation | Sample acylation (120 min) |
| ELISA | Quinolinic acid antiserum overnight incubation, revelation and read steps (1h) |
| Detailed protocol | Download instructions for use |
Product citations
- Continuous theta burst stimulation for bipolar depression: A multicenter, double-blind randomized controlled study exploring treatment efficacy and predictive potential of kynurenine metabolites
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Authors : Dellink et al., Journal of Affective Disorders
2024-09 - Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes
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Authors : Wogram et al., Immunity
2024-08 - Alteration in kynurenine pathway metabolites in young women with autoimmune thyroiditis
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Authors : Krupa et al., Sci Rep
2024-03 - The importance of oxidative stress and the kynurenine pathway of tryptophan metabolsm in the onset and development of multiple sclerosis in the population of Serbia
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Authors : Marija Vasic, Thesis
2024-02 - Advances in kynurenine analysis
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Authors : Mrstna et al., Clinica Chimica Acta
2023-07 - Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
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Authors : Dongen et al., bioRxiv
2023-07 - Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
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Authors : Girithar et al., British Journal of Cancer
2023-04 - Unlocking the Secrets: Exploring the Biochemical Correlates of Suicidal Thoughts and Behaviors in Adults with Autism Spectrum Conditions
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Authors : Cremone et al., Biomedicines
2023-04 - Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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Authors : Sugisawa et al., Cell reports
2022-03 - Apathy is not associated with a panel of biomarkers in older adults with HIV disease
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Authors : Wood et al., Journal of psychosomatic research
2021-11 - Electrochemical Determination of Kynurenine Pathway Metabolites—Challenges and Perspectives
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Authors : Sadok et al., Sensors
2021-10 - Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial
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Authors : Chaiyasut et al, Foods
2021-07
