Antibodies & immunoassays for small molecules L-Kynurenine ELISA kit High Sensitivity
Ref: BA-E-2200
Kynurenine pathwayTryptophan metabolismDiagnostic ELISA kits (IVD)Research ELISA kits (RUO)ELISA
+L-Kynurenine ELISA kit
DatasheetMSDSIVD Protocol RUO Protocol
The L-Kynurenine ELISA is an easy-to-use assay tailored for the quantification of Kynurenine across large series of samples. Optimized for the analysis of biological fluids (plasma, cell culture supernatant, serum…), the KYN ELISA features a lower limit of detection at 45.7ng/ml and a minimal sample volume of 20µl, thus allowing longitudinal studies in mice.
| Sample type | Plasma, serum, cell culture supernatant |
| Capacity | 96 tests |
| Sensitivity | < 45.7ng/ml |
| Range | 100 – 10000ng/ml |
| Assay time | Sample acylation 90 min, ELISA overnight |
| Reactivity | Reacts with all species |
| References | Cited in 70 papers |
They published with this product see papers
Product overview
| Product name | L-Kynurenine ELISA kit |
| Description | Enzyme immunoassay (ELISA) for the quantitative determination of L-Kynurenine in biological fluids and cell supernatant |
| Format | 96-well plate |
| Samples | Plasma, serum, cell culture supernatant |
| Minimal sample volume | 20µL |
| Reactivity | Reacts with all species |
| Standard range | 0/100 – 10000ng/ml |
| Sensitivity |
< 47.5ng/ml |
| Specificity | No significant cross-reactivity was observed with L-Kynurenine analogs such as L-Tryptophan, 3-Hydroxy-DL-Kynurenine, 5-Hydroxy-DL-Tryptophan, Tyrosine, Serotonin, Phenylalanin, L-Asparagine and Kynurenic acid |
| Assay time | Sample acylation 90 min and ELISA overnight |
| Storage | Store at 2-8°C for to 6 months |
| Datasheets | Instructions for use, Material Safety Datasheet |
| Sample collection & storage | Plasma/Serum: Do not use lipemic, haemolytic samples, as well as samples containing precipitates or fibrin strands. Store smaples at 2-8°C for up to 48h or -20°C for longer period (up to 6 months) |
| Sample preparation | Sample acylation (90 min) |
| ELISA | L-Kynurenine antiserum overnight incubation, revelation and read steps (1h) |
| Detailed protocol | RUO: Download instructions for use |
Product citations
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Authors : R Gonzalez-Ponsand & JJ Bernard, Front Oncol.
2024-09 - Continuous theta burst stimulation for bipolar depression: A multicenter, double-blind randomized controlled study exploring treatment efficacy and predictive potential of kynurenine metabolites
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Authors : Dellink et al., Journal of Affective Disorders
2024-09 - Transcriptomic evidence of immune modulation in subjects with chronic Trypanosoma cruzi infection
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Authors : Ros-Lucas et al., J Infect Dis.
2024-08 - Surface-Enhanced Raman Scattering Monitoring of Tryptophan Dynamics in 3D Pancreatic Tumor Models
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Authors : Valera et al., ACS Sensors
2024-07 - Induction of indoleamine 2,3-dioxygenase 1 expression in neurons of the central nervous system through inhibition of histone deacetylases blocks the progression of experimental autoimmune encephalomyelitis
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Authors : Kim CE et al., Int Immunopharmacol.
2024-06 - VEEV TC-83 Triggers Dysregulation of the Tryptophan–Kynurenine Pathway in the Central Nervous System That Correlates with Cognitive Impairment in Tg2576 Mice
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Authors : Fongsaran C. et al., Pathogens
2024-05 - Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process
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Authors : Cecchi M. et al., Pharmaceuticals
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Authors : Vaughan et al., Front. Cell. Infect. Microbiol.
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Authors : Jiménez-Trejo F. et al., Int. J. Mol. Sci.
2024-03 - PABPC1L induces IDO1 to promote tryptophan metabolism and immune suppression in renal cell carcinoma
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Authors : Shu G. et al, Cancer Res
2024-02 - The dangerous “West Coast Swing” by hyperglycaemia and chronic stress in the mouse hippocampus: Role of kynurenine catabolism
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2023-08 - Effects of Supplementation with the Standardized Extract of Saffron (affron®) on the Kynurenine Pathway and Melatonin Synthesis in Rats
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2023-07 - Advances in kynurenine analysis
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Authors : Mrstna et al., Clinica Chimica Acta
2023-07 - Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
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Authors : Dongen et al., bioRxiv
2023-07 - Involvement of the kynurenine pathway in breast cancer: updates on clinical research and trials
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Authors : Girithar et al., British Journal of Cancer
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Authors : Cremone et al., Biomedicines
2023-04 - Tryptophan degradation enzymes expression in the placenta and the Kynurenine/Tryptophan ratio in maternal plasma after elective cesarean section
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Authors : Silvano et al., Journal of Reproductive Immunology
2023-02 - Citrulline and kynurenine to tryptophan ratio: potential EED (environmental enteric dysfunction) biomarkers in acute watery diarrhea among children in Bangladesh
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Authors : Das et al., Scientific Reports
2023-01 - Priming Mesenchymal Stem/Stromal Cells with a Combination of a Low Dose of IFN- and Bor_tezomib Results in Potent Suppression of Pathogenic Th17 Immunity Through the IDO1-AHR Axis
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Authors : Park et al., Stem Cells
2022-10 - Tryptophan degradation enzymes and Angiotensin (1−7) expression in human placenta
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Authors : Silvano et al., Journal of Reproductive Immunology
2022-09 - IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma
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Authors : Struckmeier et al., Journal of Cancer Reasearch & Clinical Oncology
2022-08 - Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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Authors : Sugisawa et al., Cell reports
2022-03 - Tryptophan Metabolism Is Associated with BMI and Adipose Tissue Mass and Linked to Metabolic Disease in Pediatric Obesity
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Authors : Lischka et al, Nutrients
2022-01 - Kynurenine induces T cell fat catabolism and has limited suppressive effects in vivo
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Authors : Siska et al., eBioMedicine
2021-12 - Cancer-associated fibroblasts educate normal fibroblaststo facilitate cancer cell spreading and T-cell suppression
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Authors : Itoh et al., Molecular Oncology
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Authors : Pospíšková et al., Pteridines
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Authors : Kim et al., Oncoimmunology
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Authors : Francikowski et al., Scientific reports
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Authors : Bekki et al., PloS one
2020-10 - Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
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Authors : Baumgartner et al., Journal of internal medicine
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Authors : Adu-Gyamfi et al., International journal of infectious diseases
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2019-05 - Exercise training impacts skeletal muscle gene expression related to the kynurenine pathway
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Authors : Allison et al., American Journal of Psycology
2019-01 - Traumatic injury leads to inflammation and altered tryptophan metabolism in the juvenile rabbit brain
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Authors : Zhang et al., Journal of Neurotrauma
2018-09 - Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice
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Authors : Walker et al., Molecular Psychiatry
2018-07 - Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats
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Authors : Martin-Hernandez et al., Molecular Neurobiology
2018-05 - Dysbiosis of the Vaginal Microbiota and Higher Vaginal Kynurenine/Tryptophan Ratio Reveals an Association with Chlamydia trachomatis Genital Infections
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Authors : Ziklo et al., Frontiers in cellular and infection microbiology
2018-01 - In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
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2017-07 - The peroxyl radical-induced oxidation of Escherichia coli FtsZ and its single tryptophan mutant (Y222W) modifies specific side-chains, generates protein cross-links and affects biological function
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Authors : Escobar-Alvarez et al., Free radical biology & medicine
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2017-02
