Quinolinic acid Antibody – Mouse Monoclonal
Ref: IS002
Tryptophan metabolismToxinsMonoclonal AntibodiesICCIFIHCKynurenine pathway

Quinolinic acid detection in human midbrain by immunohistofluorescence (IHF) Quinolinic acid detection in human midbrain by immunohistofluorescence (IHF) Quinolinic acid detection in human midbrain by immunohistochemistry (IHC) Anti- Quinolinic acid antibody affinity & specificity Quinolinic acid Quinolinic acid detection in human midbrain by immunohistofluorescence (IHF)
Immunofluorescence staining highlights nuclear exclusion of Quinolinic acid in human midbrain. Paraffin-embedded brain tissue section was subjected to pH=9 antigen retrieval followed by overnight incubation with primary anti-Quinolinic acid antibody (dilution 1/250). After incubation with Alexa-555 conjugated secondary Ab, epifluorescence microscopy (100X) was used to visualize the staining.
DatasheetMSDS
This mouse monoclonal antibody to Quinolinic acid was validated for IF & IHC in human brain tissues. It was recently used in 3 papers to evidence the role of Quinolinic acid in atherogenesis & glioblastoma.
Clonality | Monoclonal antibody (clone 4E11-G3) |
Host | Mouse |
Valided applications | IHC / IF |
Reactivity | Reacts with all species |
References | Not yet cited to our knowledge Submit content and get a 10% discount! |
Format | 50µL |
References | Cited in 4 papers |
Size | 50µL |
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449.00€
71 in stock
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They published with this product see papers
Product overview
Product name | Quinolinic acid antibody |
Synonyms | Pyridine-2,3-dicarboxylic acid antibody
2,3-pyridinedicarboxylic acid antibody 3,4-Pyridinedicarboxylic acid antibody Pyridine-3,4-dicarboxylic acid antibody |
Immunogen | Conjugated quinolinic acid |
Isotype | IgG1 k chain |
Clone | clone 4E11-G3 |
Specificity | When tested in competitive ELISA, the anti-Quinolinic acid antibody did not show any significant cross reactivity with Picolinic and Quinaldic acid conjugates |
Storage
Form | Liquid |
Purity | Purified IgG |
Concentration | 0,5mg/ml |
Storage |
Store at +4°C for short term (1-2 months). Aliquot and store at -20°C for long term. Avoid repeated freeze / thaw cycles |
Material safety datasheet | Download MSDS |
Immunohistochemistry (IHC) | Dilute at 1:100-1:1000. Perform heat antigen retrieval (pH=9) before initiating IHC staining protocol on paraffin-embedded and frozen sections |
Immunofluorescence (IF) | Dilute at 1:50-1:500 on paraffin-embedded and frozen sections. Perform heat antigen retrieval and incubate fluorescent dyes conjugated secondary antibody |
Comments | Optimal working dilutions must be determined by the end-user |
Restrictions | For research use only |
Product citations
- The dangerous “West Coast Swing” by hyperglycaemia and chronic stress in the mouse hippocampus: Role of kynurenine catabolism
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Authors : Gliozzi M et al., Pharmacological Research
2024-01 - Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis
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Authors : Dongen et al., bioRxiv
2023-07 - Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis
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Authors : Kesarwani et al., Nature Communications
2023-03 - Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
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Authors : Sugisawa et al., Cell reports
2022-03