The IS1006 is a rabbit-derived polyclonal antibody designed for the specific detection of gamma-aminobutyric acid (GABA). It is widely used in neuroscience research to visualize GABAergic systems and has been validated for immunofluorescence applications. When used with the STAINperfect™ immunostaining kit A, this antibody provides optimal sensitivity and consistent results in neuronal samples.

This antibody is validated for immunofluorescence and works effectively in primary neuronal cultures, whole mounts, and tissue sections. It has been successfully applied to mouse and rat primary neurons, human iPSC-derived neurons, and rabbit brain tissues, making it a versatile option for studying GABA distribution across different models.

IS1006 shows reactivity across multiple species. It has been tested and proven effective in rodents, rabbits, and human neuronal samples, ensuring broad applicability for researchers working on various experimental models.

For optimal staining performance, it is recommended to use IS1006 in combination with the STAINperfect™ immunostaining kit A. This approach ensures reliable detection of GABA in cell cultures, tissue sections, and whole mounts. Following the validated protocols provided by ImmuSmol will help achieve high-quality and reproducible results.

Unlike monoclonal antibodies that recognize a single epitope, this rabbit polyclonal antibody targets multiple epitopes on GABA, resulting in enhanced sensitivity and robust signal detection. Its rabbit origin makes it highly compatible with antibodies raised in other species, such as mouse or chicken, allowing easy integration in multiplex imaging experiments. This antibody is also supported by peer-reviewed publications, confirming its reliability in different neuronal contexts.

Each vial of IS1006 contains 50 microliters, which is generally sufficient for around 40 tissue sections, depending on the staining conditions and protocols used in the laboratory.

Yes, the rabbit polyclonal anti-GABA antibody has been cited in studies investigating neuronal structures in rabbits, rodent primary neuron models, and human iPSC-derived neurons. These references underline its scientific relevance and established use in neuroscience research.

ImmuSmol provides a full range of anti-GABA antibodies to complement IS1006. For instance, the chicken polyclonal anti-GABA antibody (IS1036) is particularly useful for multiplex experiments, while the mouse monoclonal antibody offers high specificity for organoid and tissue applications. All antibodies are designed to work with the STAINperfect™ kits for consistent results.

Rabbit polyclonal antibodies are known for their strong immune response and the production of high-affinity antibodies that recognize multiple epitopes. This provides a more sensitive and flexible tool compared with single-epitope monoclonal antibodies. Choosing a rabbit antibody also facilitates multiplexing with antibodies from other host species.

IS1006 is provided in a standard 50 microliter vial, corresponding to approximately 40 tissue sections. The current price listed by ImmuSmol is €449, aligning with the company’s GABA antibody range.