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Anxiety and depression, autism, cognitive decline, gut motility and intestinal inflammation disorders, … Abnormal serotonin levels are detected in a […]

On June 19th, Immusmol hosted a webinar about midbrain organoid models of Parkinson’s disease. Prof. Jens Christian Schwamborn (LCSB / OrganoTherapeutics) […]

Dopamine, Serotonin, GABA, Glutamate, Histamine, Norepinephrine, Serine, Octopamine, … To generate spatial information about key neuromodulators and neurotransmitters, neurobiologists typically perform stainings against enzymes (e.g. TH for dopamine, GAD65-67 for GABA), receptors (e.g. Glutamate) or transporters (e.g. Norepinephrine, Glutamate). Why?

TH expression does not necessarily indicate that neurons are metabolically active and produce dopamine. Therefore, several groups interested in organoid-based modeling of Parkinson’s disease have combined standard markers of dopaminergic neurons, such as TH and GIRK2, with direct staining of dopamine using anti-hapten antibodies, as well as ELISA kits for quantifying dopamine release in supernatant.

Catch up on our top highlights from this year!

Hear about our new ELISA kits and antibodies to assess the polyamine pathway and reveal serotonin, as well as the peer-reviewed papers that referenced our products!

Benefit from our current special offer on a range of specific and highly sensitive ELISA kits to obtain valuable quantitative data on monoamine levels in various fluids, including blood and urine.

Serotonin (5HT) is one of the most potent monoamine neurotransmitters and peripheral signaling molecules. Therefore, tools allowing for the evaluation of serotonergic systems are valuable to approach the complex 5HT activities in physiological and pathological situations, but also to investigate mechanisms of action of novel disease-targeting therapies. For this purpose, we have set up and validated a series of experimental immunoassays specifically raised against 5HT.

Given the importance of the polyamine pathway in cancer progression and resistance to treatment, investigating it requires robust tools. To this aim, we developed and validated the first ELISA kits to quantify ornithine, N1-acetylspermidine, and N8-acetylspermidine in samples of different natures (plasma, cell culture supernatants) and different species (mouse, human).

Benefit from our current special offer on a range of specific and highly sensitive ELISA kits to obtain valuable quantitative data on monoamine levels in various fluids, including blood and urine.

Serotonin (5-HT) is one of the most potent monoamine neurotransmitters and peripheral signaling molecules. Physiologically, 5-HT has complex and diverse effects on the central and peripheral nervous systems, neuroendocrine regulation, and immunological responses. We recently developed and added to our catalog a novel antibody raised against 5-HT, compatible with formalin-fixed biological materials.