Scientific Communications

Through the degradation of L-Tryptophan, the Kynurenine pathway (KP) generates a series of catabolites collectively known as Kynurenines, which can exert immunomodulatory and/or neuroactive properties. Known to respectively harbor neuroprotective and neurotoxic functions, Kynurenic (KYNA) and Quinolinic (QA) acids are found to be dysregulated in several neuroinflammatory disorders including Parkinson and Alzheimer disease but also Amyotrophic Lateral Sclerosis and Multiple Sclerosis. We developed novel ELISA detection kits to monitor the imbalance between KYNA and QA levels in neurological diseases and evaluate the ability of novel KMO inhibitors to restore equilibrium within the KP and mitigate neurodegeneration.

HomoArginine (hArg) is a basic non-essential amino acid that exerts beneficial effects on vascular homeostasis, more likely through the increase of nitric oxide (NO) that can be explained through two mechanisms since hArg i) serves as a precursor of NO and ii) favors the elevation of L-Arg – main substrate of NO synthase – by inhibiting the enzyme Arginase. Our IS-I-0500 ELISA kit allows for the determination of hArg in serum and plasma samples in a minimal sample volume of 20μL and with a sensitivity of 125nM.

Kynurenine / Tryptophan ELISA pack – Special Offer!

New ELISA Kit out now for Kynurenic Acid!

Reveal Dopamine in your samples using our dedicated tools

Take the opportunity of a special offer to try our Dopamine Ab

Quinolinic Acid ELISA kit: NOW OUT!

96-w plate format / Low volume samples / Sensitive, easy-to-implement / Cross-validated with LC/MS

Kynurenine and tryptophan as surrogate immune suppression tumor biomarkers

Validated monoclonal anti-GABA antibody to evaluate GABAergic system network/function by immunofluorescence

Validated antibody to assess L-Kynurenine by IHC

Kynurenine levels measured by ELISA – Special offer

Effect of IDO1 inhibition on Kynurenine levels measured by ELISA