Antibodies & immunoassays for small molecules Quinolinic Acid ELISA kit: NOW OUT!
The Quinolinic acid (QUIN or QA) ELISA kit is an easy-to-use assay tailored for the quantification of QA across large series of samples. Optimized for the analysis of serum samples, the QA ELISA features a lower limit of detection at (6ng/mL) and a minimal sample volume (25μL), thus allowing human ancillary studies.
- 96-w plate format
- Low volume samples
- Sensitive, easy-to-implement
- Cross-validated with LC/MS
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Format |
96-well kit |
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Species reactivity |
Any species |
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Samples |
Serum |
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Sample volume |
25μL |
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Sensitivity |
< 6ng/mL |
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Assay range |
25 – 2000 ng/mL |
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Assay time |
Sample preparation: 2h ELISA: Overnight |
Scientific background
Quinolinic acid (QA) is a metabolite produced along the Kynurenine Pathway, which converts the aminoacid Tryptophan to NAD+, a co-factor of many enzymatic reactions. It has been described to share several neurotoxic functions particularly through the activation of the N-Methyl-D-Aspartate receptor. Its production occurring in myeloid cells (macrophages, microglia, etc.) is mainly driven by inflammatory stress and is therefore suspected to play a key role in neuroinflammatory disorders such as Alzheimer and Parkinson diseases but also Multiple Sclerosis, Amyotrophic Lateral Sclerosis. Hence, while QA has been proposed as a biomarker in these indications, it might certainly warrant further investigation to serve as a surrogate in other “inflammation” related diseases such as cancer, metabolic disorders, etc.